Virtual Poster Session

P01 - Federica Rapetti

DIFAR-University of Genova, Italia

Design and snthesis of new constrained GEBR library compounds as potential PDE4D inhibitors

P02 - Isabella Romeo

University of Calabria, Italia

The Antioxidant Capability of Higenamine: Insights from Theory

P03 - Gian Marco Elisi

Food and Drug Department - University of Parma, Italy

Conformational equilibria of N-anilinoethylamides for perspective design of melatonergic agonists

P04 - Nurlybek Amangeldiuly

Skolkovo Institute of Science and Technology, Russia

Transfer learning for protein-ligand binding kinetics prediction

P05 - Sergio Rodriguez

Universitat de Barcelona, Spain

A BICYCLIC a-IMINOPHOSPHONATE IMPROVES COGNITIVE DECLINE IN AN ALZHEIMER'S DISEASE MURINE MODEL

P06 - Valentina Noemi Madia

Università di Roma La Sapienza, Italia

Quinolinonyl non-diketo acid derivatives as inhibitors of the HIV-1 ribonuclease H function of reverse transcriptase

P07 - Camilla Marasca

Research Group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Italia

Multimatrix therapeutic drug monitoring of patients under antidepressant treatment

P08 - Roberta Rocca

Università Magna Graecia di Catanzaro, Italy

Identification of selective TERRA-RNA G-quadruplex binders through computational techniques.

P09 - Vittorio Canale

Department of Medicinal Chemistry, Jagiellonian University Medical College, Poland

Efficient and sustainable synthesis of a potent and selective 5-HT7 receptor antagonist using a mechanochemical approach

P10 - Sofia Parrasia

Department of Biomedical Sciences, University of Padova, Italy

Precision targeting of a mitochondrial channel in intruder cells within the brain. A new approach to brain tumors

P11 - Mihajlo Krunic

university of belgrade - institute of chemistry, technology and metallurgy, Serbia

Synthesis and preliminary docking evaluation of novel 1-benzyl-N-(4-(4-arylpiperazin-1-yl)phenyl)piperidin-4-amines, as potential acetylcholinesterase inhibitors

P12 - Manos Vlasiou

University of Nicosia, Cyprus

Interaction of Zinc Metal Ion With Drug Molecules and the Binding Effect on a Transport Protein

P13 - Carla Di Chio

University of Messina, Italy

Discovery of novel peptidomimetics containing a benzodiazepine scaffold as inhibitors of rhodesain of Trypanosoma brucei rhodesiense

P14 - Alessandra Feoli

Università degli studi di Salerno, Italy

Development of a Microscale Thermophoresis-based Method for Screening and Characterizing Inhibitors of the Methyl Lysine Reader Protein MRG15.

P15 - Pasquale Linciano

University of Pavia, Italy

Identification and full chemical characterization of novel phytocannabinoids isolated from a medical Cannabis sativa variety

P16 - Roberta Ibba

University of Sassari, Italy

Extrusion Pump Inhibitors revert Drug Resistance in MDR-Mycobacterium Tuberculosis strains

P17 - Federico Ricci

University of Messina, Italy

Discovery of new potential anti-tyrosinase agents through ligand-based pharmacophore strategy focused on competitive inhibitors.

P18 - Paolo Governa

University of Siena, Italy

Structure-based identification of P-glycoprotein inhibitors from natural sources

P19 - Serena Vittorio

University of Messina, Italy

Computational and synthetic approaches for the development of a-synuclein aggregation inhibitors for the treatment of Parkinson’s disease

P20 - Annalisa Maruca

University Magna Graecia of Catanzaro, Italy

Multi-Targeting Bioactive Compounds Extracted from Essential Oils as Kinase Inhibitors

P21 - Jakub Jurasz

Gdansk University of Technology, Polska

Molecular modeling of EmrE, multidrug transporter protein - studies by molecular dynamics simulation

P22 - Federico Riu

Università degli Studi di Sassari, Italy

Synthesis and biological evaluation of a new series of 5,6-difluorobenzotriazole-acrilonitrile derivatives as microtubule destabilising agents (MDAs)

P23 - Lisa Anceschi

Univesity of Modena and Reggio Emilia, Italia

Chemical characterization of non-psychoactive Cannabis sativa L. extracts and evaluation of their antiproliferative activity

P24 - Ivana Kuzminac

University of Novi Sad, ??????

More efficient synthesis, cytotoxicity and in silico ADME properties of 3-hydroxy-17-oxa-17a-homoestra-1,3,5(10)-trien-16-one

P25 - Marilisa Pia Dimmito

University G. D'Annunzio Chieti, Italy, Italia

Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity

P26 - Sebastiano Intagliata

University of Catania, Italy

New benzylpiperazine derivatives as selective s1 receptor ligands: synthesis, in vitro and in vivo pharmacological characterization

P27 - Marianna Bufano

Sapienza University of Rome, Italy

Modeling Epac1 Interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics

P28 - Carla Barbaraci

Università degli studi di Catania, Italia

SHIFT IN ACTIVITY OF CIPROFLOXACIN AND NORFLOXACIN “NO-LIGHT ACTIVATED” DERIVATIVES FROM ANTIBIOTICS TO ANTICANCER AGENTS: PRELIMINARY RESULTS

P29 - Marilia Barreca

University of Palermo, Italy

Screening of [1,2]oxazolo[5,4-e]isoindoles in lymphoma models

P30 - Santo Previti

Institut des Biomolécules Max Mousseron (IBMM), University of Montpellier, France

Neurotensin, a multi-faceted peptide

P31 - Chiara Lo Caputo

Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Francia

Design and synthesis of small molecules to disrupt XIAP/Caspase interaction

P32 - Vera Isca

University of Lisbon, Portugal

Molecular Docking Studies of Promising P-Glycoprotein Inhibitors obtained from Plectranthus spp.

P33 - Milica Ilic

University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Serbia

In silico ADME and inverse docking of A,B-modified steroidal D-homo lactones with cytotoxic properties

P34 - Laura Scalvini

University of Parma, Italia

N-Acylethanolamine Acid Amidase (NAAA): Mechanism of Palmitoylethanolamide Hydrolysis Revealed by Mechanistic Simulations

P35 - Francesca Alessandra Ambrosio

University Magna Graecia of Catanzaro, Italy

Preparation and HuR interaction studies of BOPC1 enantiomers combining DEEP-STD NMR and molecular modeling analysis.

P36 - Massimiliano Runfola

University of Pisa, Italy

A follow-up study on new synthetic thyroid hormone analogues: identification of new treatments for Transthyretin Amyloidosis

P37 - Francesca Ferlenghi

Università di Parma, Italia

Enzymatic and cell-based characterization of the inhibitory mechanism of UPR1444 on EGFR by TR-FRET-based assays and liquid chromatography-mass spectrometry analysis

P38 - Valeria Cavalloro

University of Pavia, Italy

(-)-(S)-usnic acid from Cladonia foliacea: microwave assisted extraction and cytotoxic profile

P39 - Antonino Nicolò Fallica

Università degli Studi di Catania, Italy

RATIONAL DESIGN AND SYNTHESIS OF HEME OXYGENASE 2 (HO-2) INHIBITORS BY TARGETING THE SECONDARY HYDROPHOBIC POCKET OF THE HO-2 WESTERN REGION

P40 - Giulia Iannelli

Università degli studi di Salerno , Italia

Identification of new inhibitors of Protein Arginine Methyltransferases by a Multi-substrate-adduct approach

P41 - Roberta Listro

University of Pvia, Italy

Looking for new agents against multiple myeloma: exploration of the chemical space of the PAN-sigma receptor modulator RC-106

P42 - Matteo Mori

Department of Pharmaceutical Sciences, University of Milan, Italy

Investigating the inhibition mechanism and catalytic cycle of MbtI, the salicylate synthase from Mycobacterium tuberculosis

P43 - Greta Bagnolini

Italian Institute of Technology-University of Bologna, Italy

Dihydroquinolone pyrazoline-based compound as a new RAD51-BRCA2 protein-protein disruptor to trigger synthetic lethality in pancreatic cancer

P44 - Cinzia Citti

Mediteknology s.r.l. (spin-off company of CNR), Italy

Isolation and pharmacological evaluation of ?9-tetrahydrocannabiphorol, the new heptyl homologue of tetrahydrocannabinol: new insights on cannabis research

P45 - Claudia Ardino

University of Siena, Italy

Targeting the viral envelope: synthesis and biological evaluation of novel broad-spectrum antivirals.

P46 - Irene Brusa

University of Bologna Alma Mater Studiorum, Italy

Hit optimization for the development of novel rnf5 inhibitors as therapeutic strategy in cystic fibrosis

P47 - Francesca Mancuso

University of Messina, Italy

Design, synthesis and structural studies of novel piperazine-based sulfonamides as potent human carbonic anhydrases (hCAs) inhibitors

P48 - Deborah Palazzotti

University of Perugia, Italy

Small-molecule inhibitors targeting AKT1 active and allosteric sites

P49 - Marco Ballarotto

Università degli Studi di Perugia, Italy

Straightforward synthesis of highly functionalized benzo[c]chromenes by Diels-Alder cycloaddition/aromatization sequence

P50 - Niccolò Cantini

University of Florence, Italy

Further exploration of different Nitrogen heterocycle scaffold as potent HNE inhibitors

P51 - Marco Cirrincione

Pharmaco Toxicological Analysis Laboratory (PTA Lab) Department of Pharmacy and Biotechnology (FaBiT) Alma Mater Studiorum – University of Bologna, Italia

Capillary volumetric microsampling for the evaluation of methadone use and misuse

P52 - Giulia Cazzaniga

University of Milan, Italy

A dual-target approach in anti-tuberculosis therapy: new MptpB/MbtI inhibitors

P53 - Jasmine Esposito Salsano

University of Pisa, Italy

Nutraceutical Extract from autochthonous Tuscan olive leaves incorporated in poly(Hydroxybutyrate-co-Hydroxyvalerate) (PHBHV) for medical application

P54 - Kyriaki Pafiti

University of Nicosia, Cyprus

Oligo(ethylene imine)-grafted Linear and Star Homopolymers for DNA delivery: Odd-Even Correlated Transfection Efficiency

P55 - Alessandra Cipriano

Università degli Studi di Salerno, Italia

Identification of benzimidazole-based compounds as selective ligands for the first bromodomain of BET proteins: rational design, synthesis and in vitro evaluation.

P56 - Samuele Ciceri

University of Milan, Italy

Biocatalytic synthesis of two pharmacologically active compounds: (S)-pramipexole and its enantiomer, dexpramipexole

P57 - Andrea Mammoli

University of Perugia, Italy

Molecular Recognition Properties of IDO1 Crystal Structures: Computational and Biophysical Studies

P58 - Giuseppina Ioele

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Italy

A challenge in the treatment of neuropathic pain: synthesis of new photostable dihydropyridines

P59 - ANDREA BAGAN POLONIO

UNIVERSITY OF BARCELONE, Espanya

(2-Imidazolin-4-yl)phosphonates as Imidazoline I2 Receptor Ligands for Neurodegenerative Diseases

P60 - CARMEN ESCOLANO

UNIVERSITY OF BARCELONE, SPAIN

Benzofuranylimidazoles: synthesis, affinity for imidazoline I2 receptors and improvement in the cognition of 5xFAD mouse model

P61 - Claudia Albertini

University of Bologna, Italia

A single-molecule based polypharmacological approach against Alzheimer’s disease

P62 - Mariagrazia Rullo

Università degli Studi di Bari Aldo Moro, Italy

Fluorine Impact on the Drug-like Profile of MTDLs against Alzheimer’s Disease

P63 - Andreea Larisa Turcu

Universidad de Barcelona, España

A NEW THERAPEUTIC APPROACH FOR ALZHEIMER’S DISEASE: NOVEL P2X7 RECEPTOR ANTAGONISTS

P64 - Michela Puxeddu

La Sapienza, University of Rome, Italy

Novel 3 Aroyl-1,4-diarylpyrroles against Solid Tumors and Hematological Malignancies

P65 - Epole Ntungwe

University of Alcalá, Portugal

Natural Cytotoxic Diterpenoids, as Potential Source of Drug Leads for cancer Therapy

P66 - Sveva Pelliccia

University of Naples-Department of Pharmacy, Italy

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